Cannabis that won't make you stoned

School of Biological and Chemical Sciences
Scientists from Queen Mary, University of London, have discovered a new way to separate the therapeutic benefits of cannabis from its mood-altering side-effects.

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THC binds to and activates proteins in the brain known as 'CB1 cannabinoid receptors'. Activating these receptors can relieve pain and prevent epileptic seizures; but it also causes the mood-altering effect experienced by people who use cannabis as a recreational drug.

Now, SBCS's Professor Maurice Elphick and Dr Michaela Egertová may have found a way of separating out the effects of cannabis – a discovery which could lead to the development of new medicines to treat conditions such as epilepsy, obesity and chronic pain. The research is described in the December 2007 issue of the journal Molecular Pharmacology.

Working in collaboration with scientists from the Department of Pharmacology and Toxicology at the Medical College of Georgia, USA, they have identified a protein that binds to the CB1 receptors in the brain. But unlike THC, this 'Cannabinoid Receptor Interacting Protein' or CRIP1a, suppresses the activity of CB1 receptors.

Professor Elphick explains: "Because CRIP1a inhibits the activity of the brain’s cannabinoid receptors, it may be possible to develop drugs that block this interaction, and in turn enhance CB1 activity. This may give patients the pain relief associated with CB1 activity, without the 'high' that cannabis users experience."

However, other scientists question the utility of such process, since Schizophrenia risk is not influenced by variations in the cannabinoid receptor, as reported by UK researchers, who have found no evidence for the purported effects of cannabis use on schizophrenia according to variation in the catechol-O-methyltransferase (COMT) gene.

Schizophrenia is associated with an increased use of tobacco and cannabis, with evidence suggesting that patients may use the drug to alleviate neurophysiological symptoms. The benefits of these substances are thought to be mediated through their effects on CHRNA7 and CNR1, respectively, notes the team.

They therefore looked at the effects of variants in the genes encoding CHRNA7 and CNR1 on the risk for schizophrenia and the potential effects of tobacco and cannabis use.

Stanley Zammit, from Cardiff University, and colleagues genotyped 750 patients with schizophrenia and 688 mentally healthy controls for the CHRNA7 promoter polymorphism -86C/T and the CNR1 polymorphism rs1049353. They also gathered information on tobacco and cannabis use via interviews and case-note records.

In addition, the team conducted a case-only study of 493 participants from the schizophrenia group, examining interactions between cannabis use and the Val158Met polymorphism in the COMT gene, as well as the rs737865 and rs165599 single nucleotide polymorphisms (SNPs).

The team reports in the British Journal of Psychiatry that there was no evidence of an association between the CHRNA7 -86C/T genotype and schizophrenia. Schizophrenia patients were 4.4 times more likely than controls to smoke, but among the schizophrenia patients, there was no association between tobacco use and the -86C/T genotype.

Similarly, there was no significant association between the CNR1 rs1049353 genotype and schizophrenia. Schizophrenia patients were 2.6 times more likely than controls to use cannabis, but cannabis use was not affected by rs1049353 genotype among schizophrenia patients.

The results also showed that there were no associations between the Val158Met genotype and cannabis use, or between cannabis use and the variations at rs737865 and rs165599.

The only genetic effect on phenotypes of schizophrenia was a weak association between the -86C/T genotype and a younger age at onset of schizophrenia.

“In summary, we failed to find any evidence that variation at the CHRNA7 or CNR1 locus was associated with schizophrenia, or that the effect of variation at these loci was modified by use of tobacco or cannabis, respectively,” the researchers write.

They add: “Cannabis use was not associated with the presence of valine allele at Val158Met with COMT in our sample, therefore our findings do not support a previous report of a putative gene–environment interaction between COMT genotype and cannabis use on risk of schizophrenia.”

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Hollyweed Festival

It will take place on November 8th.9th,, 10th and 11th, 2007 at the Centro Arte Alameda Alameda 139, Santiago de Chile.

Organized by:
The Objectives of this Festival are to help to generate a change of mentality in Chile about the topics associated to psycho actives substances by means of a participated and democratic dialogue present in the audiovisual arts.
It is also intended to give Chilean and foreign audiovisual producers a space for diffusion and competition, promoting the artistic and technical quality production and making easier the contacts and creating new support networks.

All films and cultural expressions wishing to participate in this Festival must be related in a clearly and directly way to psychoactive substances (natural, legal or illegal) and/or to different phenomenon associated to it (social, cultural, politics, penalty law, economics); including any kind of use (recreational, experimental, therapeutic, social) and even self cultivate.

The pre-selection format film, in any category, must be on DVD

The screenplay format, in any category, should be on DVD or Mini DV, required for pre-selected films, although they will also accept copies with NTSC or PAL•
Every film, for all categories in competition, must be displayed in Spanish version or with Spanish subtitles.

The Categories of the Festival are as follows:
  1. a) Documentary: Official competition for documentary work no longer than 120 minutes (credits included). Will be able compete any documentary finished since January 2005 and ahead.
  2. b) Fiction: Official competition for fiction work no longer than 120 minutes (credits included). Will be able compete any documentary finished since January 2005 and ahead.
  3. c) Animation: Official competition for animation work no longer than 15 minutes (credits included). Will be able compete any documentary finished since January 2005 and ahead.
  4. d) Self-cultivation (special category): Official competition to all films, fiction or documentary, involved in Self-cultivation topic for some psychoactive species. Maximum extension: 60 minutes. Will be able compete any documentary finished since January 2005 and ahead.

The Festival is gibing the followings awards:
  1. Best Motion Film in documentary category
  2. Best Motion Film in fiction category
  3. Best Animated Short film
  4. Special Award: Best Film Self-cultivation Category
  5. Audience Award (chosen by Internet, at

The jury will be conformed by outstanding people from the Chilean audiovisual, arts and national culture world.

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Using Spider-Web Patterns To Determine Toxicity

SPIDERS on marijuana are so laid back, they weave just so much of their webs and then ... well, it just doesn't seem to matter any more. On the soporific drug chloral hydrate, they drop off before they even get started.

A spider's skill at spinning its web is so obviously affected by the ups and downs of different drugs that scientists at NASA's Marshall Space Flight Center in Alabama think spiders could replace other animals in testing the toxicity of chemicals.

Different drugs have varying effects on the average arachnid addict. On benzedrine, a well-known upper, the house spider spins its web with great gusto, but apparently without much planning, leaving large holes. On caffeine it seems unable to do more than string a few threads together at random.

Author(s):Noever, David A.; Cronise, Raymond J.; Relwani, Rachna A.
Abstract:Method of determining toxicities of chemicals involves recording and analysis of spider-web patterns. Based on observation spiders exposed to various chemicals spin webs that differ, in various ways, from normal webs. Potential alternative to toxicity testing on higher animals.
NASA Center:Marshall Space Flight Center
Publication Date:Apr 1, 1995
Document Source:National Technology Transfer Center (NTTC), Wheeling, WV

LSD and THC affect higher brain functions in the neocortex, an area of the brain which spiders lack.
It is highly unlikely that they would react to drugs in the same way people would.
And it is more than likely another hoax "informing us of the Dangers of Marijuana.

The Ganja Protocol

Crazy, but true. New recommendations for the tratment of Autism include marijuana. However, tongue planted firmly in cheek, mary jane might be a good idea when you consider what some of the DAN! kids go through everyday. After all, who wouldn't enjoy a doobie after getting your butt stuck with injectible vitamins, having to sit inside a toy balloon, getting sweaty in a sauna, eating rock hard GFCF food, taking your 40 pills of herbs and vitamins from Kirkman's everyday, sitting through hours of ABA, getting intravenous glutathione, having nasty sulfur smelling creams applied to your body, having all the minerals stripped out of your body from chelation, cranio-sacral therapy, getting your blood drawn to send off to suspect labs, and having to listen to your parents whine about how tough you made their lives and all they are doing for you to make you acceptable.

Therapeutic Help from Cannabis for Multiple Sclerosis

Therapeutic Help from Cannabis for Multiple Sclerosis

For over 5 years THC4MS supplied Canna-Biz chocolate to Multiple Sclerosis sufferers across the UK and Europe.
Following the successful prosecution of Mark Gibson, Lezley Gibson and Marcus Davies in December 2007 production ceased.
Mark, Lezley and Marcus were sentenced to 9 months imprisonment suspended for 2 years.

now continues to exist as an historical record of their work over that period.

Cannabis 'cut MS symptoms'
The biggest-ever trial of drugs based on cannabis
has confirmed the belief of multiple sclerosis patients
that they can ease their symptoms.
Read the story at BBC News:

Marijuana Uses

A very interesting website loaded with information about the different uses of Marijuana:

"I have yet to mention my favorite use of pot, alone in nature, no agenda, nothing to do, nothing to be, just unstructured time to see, smell, feel the wind, to watch the sun crash over the bay. I love to be outdoors when I am stoned, walking down alleys, the quiet streets in my neighborhood, wild desert trails, and the streets of far-flung cities and towns. The joy and sense of connection with the environment is the main reason I smoke pot.

Marijuana heightens the senses - hearing, seeing, taste, touch, and smell - and I have experienced all my senses sharpened after smoking grass."

Marijuana Uses also has some interesting Essays, Testimonials and Short Stories:

Title Author
A Cannabis Odyssey Lester Grinspoon
A Life Cycle Perspective on Cannabis Anonymous
A Little Dab Will Do You: Marijuana and Literary Composition Tim Brown
A Mental Journey Into Creativity Brandon Thomas
A School Teacher's Confession Bob Smith
A Single Episode A Gentle Person
A Way of Life Emancipated
Allen Ginsberg and Mary Jane Lester Grinspoon
Amateur's Notes "John Shade"
Basements "Dear 23"
Cannabis and Music Anonymous
Cannabis and Planetary Surfaces Anonymous
Cannabis and PTSD Michael McKenna
Cannabis and the Legend of the Sand Dollar Airie Hicks
Cannabis as a Philosophic Sacrament David
Chronic Pain From Hell Jana Christian
Cross-Cultural Discovery Tucker Clark
Dear Dr. Grinspoon Richard Pisano
Dear Honey Timothy
Dear Mom and Dad Rob
Deep Spirit and Great Heart Louis Silverstein
Discovering a Bridge Florence Siegel
Discovery Sherry Hall
Ego Trips Del Cogswell Brebner
The Emerald City of Oz "Prarie Dog"
Fat Angel Jatayu
Four Leaf Clovers Jeremy Wells
Freeing Time "Ferrell Beck"
Ganja the Musicmaker "Herb Garden"
George's Rainbow Jeff Syrop
Grass, the Exponent Harry Bailey
How I Learned I Didn't Have a Head for Ganja Jamie Gaffney
How I Use Pot Paul DeFelice
How Marijuana Ruined My Life Stephen Kessler
I Am An Addict Chris Ferguson
Lady Chatterly Stoned Robert Burruss
(Some Experiences With) Language and Learning T.D.
Living Better with Cannabis B.W.
Living Life as a Human Being Mr. O
Marijuana and Its Meaning for Me Anonymous
Marijuana and Music Peter Webster
Marijuana and My Fear of Death Anonymous
Marijuana and Spirituality Kevin Nelson
Marijuana as an Enhancer of Music Therapy Pete Brady
Marijuana as Family Medicine and Sacrament Synonymous
Marijuana, My Wonder Drug Brian C. Bennett
Marijuana Stimulates Creativity and Enhances Experience Jon Byrne, MD
Me and Mary Jane: Marijuana's Influence on My Fiction Theodore Pelton
Medicinal...Recreational...and Beyond Joel Lindau
Memories of the Moment Elizabeth Amberg
Miraculous Marijuana Paul Handshy
Mr. Barr and the Fountain of Youth Lester Grinspoon
Mr. X Carl Sagan
Mother Marijuana Dawnhuman
My Father Within Candace
My Friend Cannabis Adam Meadows
My Marijuana Experiences John Irwin
My Religious Experience "Rich Goss"
On Marijuana, Musical Creativity, and the Collective Unconscious Russell Ambrose
Pot: My Drug of Choice "Simona Place"
Pot: Not Just a Phase D.S.
Pot and Poetry Floyd Salas
Pot in Prison Anonymous
Pot to Alleviate Alcoholism A Working Mother
Puffy World Bootsy B.
Reefer Sanity Anonymous
Restoration of the Body Anonymous
Stress Control Doug Dusalle
THC and the Topical Gag Jeff Ward
The Case of the Conscious Connoisseur Anonymous
The Composition of Music Anonymous
The Great Marijuana Hoax Allen Ginsberg
The Healthy Effects of Marijuana "Mark James"
The Laidback Meerkat New "Carla"
The Old Pothead Poems Sam Abrams
The Screening Room Doug Magee
The Senses Anonymous
The Spice of Life Martin Martinez
Twinkly Twinkly
Up From Illegitimacy Anonymous
We're Not Bluffing Anymore E. Cleaves
What Marijuana has Done for Me Steven

Title Author
A Musician Describes His Use of Marijuana for Creative Purposes Anonymous
A Scientist Reports on the Contribution of Cannabis to His Work Anonymous
After Two Decades of Just Saying No, I Finally Said Yes! Sergio Reyes
Cannabis Through the Years KNL
Elevating Consciousness MCLH86
Experiencing Highs to Deepen Understanding Wendy from Australia
Father's Little Helper? George De La Cruz
Marijuana and College Anonymous
Marijuana and Religion Nimsu
Nature's Remedy Andre
Parenting T K